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1– 4 A common trend in this ongoing discussion is the capability to operate on a scale small enough to interact with intracellular components including DNA. Nanotechnology in medicine has been recently reviewed (2002-present) from various perspectives relative to the human molecule-tissue interface. Finally, plausible “next-phase” trends in current nanorestorative research are judiciously examined, including 1) calcium-, phosphate-, and fluoride-ion-releasing nanocomposites for anticaries applications and 2) restorative systems based on biomimetic emulation of the nanomolecular assembly processes inherent in dental enamel formation using nanorods, nanospheres, and recombinant amelogenins. Available comparative data for nanocomposites and organically-modified ceramic (Ormocer ®) restoratives are also reviewed.

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Characterized by filler-particle sizes of ≤100 nm, these materials can offer esthetic and strength advantages over conventional microfilled and hybrid resin-based composite (RBC) systems, primarily in terms of smoothness, polishability and precision of shade characterization, plus flexural strength and microhardness similar to those of the better-performing posterior RBCs.

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Part 1 of a three-part series reviews the current clinical utility of nanotechnology’s most tangible contribution to dentistry to date: the restoration of tooth structure with nanocomposites.

While many layers of nanotechnologic capability have been envisioned for oral health in the last decade (eg, oral hygiene maintenance, local anesthesia, even whole-tooth replacement), few of these applications have been developed.

Nanoparticles, nanospheres, nanorods, nanotubes, nanofibers, dendrimers and other nanostructures have been studied for various applications to biologic tissues and systems. First described in 1959 by physicist Richard P Feynman, who saw it as an unavoidable development in the progress of science, nanotechnology has been part of mainstream scientific theory with potential medical and dental applications since the early 1990s.

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